{"id":12671,"date":"2026-02-07T15:16:26","date_gmt":"2026-02-07T11:16:26","guid":{"rendered":"https:\/\/medscriptum.org\/scor2-cximis-gadamrtveli-fermenti-mkurnaloba-siaxl\/"},"modified":"2026-02-07T15:25:05","modified_gmt":"2026-02-07T11:25:05","slug":"scor2-cximis-gadamrtveli-fermenti-mkurnaloba-siaxl","status":"publish","type":"post","link":"https:\/\/medscriptum.org\/en\/scor2-cximis-gadamrtveli-fermenti-mkurnaloba-siaxl\/","title":{"rendered":"What is SCoR2, a fat-switching enzyme that has the potential to treat three diseases at once?"},"content":{"rendered":"<p data-path-to-node=\"4\">\n<p data-path-to-node=\"4\">A scientific breakthrough has identified a previously unknown metabolic \u201cfat switch\u201d enzyme that plays a crucial role in how the body produces and stores fat. The study was conducted by researchers at University Hospitals Cleveland Medical Center and Case Western Reserve University. By blocking this enzyme in animal models, scientists were able to stop weight gain and improve metabolic health markers, paving the way for new drugs to treat obesity, fatty liver disease, and cardiovascular disease.<\/p>\n<p data-path-to-node=\"5\"><strong>The Essence of the Discovery<\/strong><\/p>\n<p data-path-to-node=\"5\">In a study published in <a href=\"https:\/\/www.sciencedaily.com\/releases\/2026\/02\/260206012226.htm\" target=\"_blank\" rel=\"noopener\"><i data-path-to-node=\"5\" data-index-in-node=\"53\">Science Signaling<\/i><\/a>, researchers identified the enzyme SCoR2, which is an essential component for fat production in the body. The research showed that SCoR2 acts as a &#8220;switch&#8221; through the following mechanism:<\/p>\n<ul data-path-to-node=\"6\">\n<li>\n<p data-path-to-node=\"6,0,0\">Mechanism: Certain proteins in the body naturally suppress fat synthesis. Nitric oxide (<span class=\"math-inline\" data-math=\"NO\" data-index-in-node=\"88\">NO<\/span>) acts as a &#8220;brake&#8221; for these proteins. The SCoR2 enzyme removes nitric oxide from these proteins, thereby releasing the brake and turning &#8220;ON&#8221; the fat production process.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"6,1,0\">Experimental Results: When SCoR2 was blocked genetically or with a specific drug in mice, the results were remarkable:<\/p>\n<ul data-path-to-node=\"6,1,1\">\n<li>\n<p data-path-to-node=\"6,1,1,0,0\">Weight Control: Animals did not gain weight even on diets that typically cause obesity.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"6,1,1,1,0\">Healthy Liver: Fat accumulation in the liver and tissue damage markers significantly decreased.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"6,1,1,2,0\">Heart Health: Levels of harmful cholesterol dropped substantially.<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"7\">Lead author Dr. Jonathan Stamler explains that this discovery allows for the creation of a new class of medicines targeting multiple chronic diseases simultaneously, rather than treating each symptom separately.<\/p>\n<p data-path-to-node=\"8\">\n<p data-path-to-node=\"8\">The potential of this interesting enzyme for combination with or replacement of other <a href=\"https:\/\/medscriptum.org\/en\/study-ozempic-improves-blood-sugar-control-and-weight-loss-in-patients-on-antipsychotic-treatment\/\">weight-loss drugs<\/a> already available on the marketThe identification of the SCoR2 enzyme as a key regulator of fat metabolism is a turning point in metabolic disease research. Unlike traditional approaches focused solely on calorie restriction, this method targets the biological mechanism of fat production itself. The research team expects human clinical trials to begin in approximately 18 months. If successful, this could lead to a &#8220;triple-action&#8221; drug that fundamentally changes obesity treatment strategies.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A scientific breakthrough has identified a previously unknown metabolic \u201cfat switch\u201d enzyme that plays a crucial role in how the body produces and stores fat. The study was conducted by researchers at University Hospitals Cleveland Medical Center and Case Western Reserve University. By blocking this enzyme in animal models, scientists were able to stop weight [&hellip;]<\/p>\n","protected":false},"author":28,"featured_media":12668,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1596,1594,1587],"tags":[],"class_list":["post-12671","post","type-post","status-publish","format-standard","has-post-thumbnail","category-internal-medicine","category-news","category-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/medscriptum.org\/en\/wp-json\/wp\/v2\/posts\/12671","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medscriptum.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medscriptum.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medscriptum.org\/en\/wp-json\/wp\/v2\/users\/28"}],"replies":[{"embeddable":true,"href":"https:\/\/medscriptum.org\/en\/wp-json\/wp\/v2\/comments?post=12671"}],"version-history":[{"count":3,"href":"https:\/\/medscriptum.org\/en\/wp-json\/wp\/v2\/posts\/12671\/revisions"}],"predecessor-version":[{"id":12678,"href":"https:\/\/medscriptum.org\/en\/wp-json\/wp\/v2\/posts\/12671\/revisions\/12678"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medscriptum.org\/en\/wp-json\/wp\/v2\/media\/12668"}],"wp:attachment":[{"href":"https:\/\/medscriptum.org\/en\/wp-json\/wp\/v2\/media?parent=12671"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medscriptum.org\/en\/wp-json\/wp\/v2\/categories?post=12671"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medscriptum.org\/en\/wp-json\/wp\/v2\/tags?post=12671"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}