Research: Stress experienced in childhood causes chronic digestive issues in adults

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According to a new study published in the journal Gastroenterology, stress experienced during childhood may lead to chronic digestive system problems in adulthood. Researchers at New York University (NYU) have found that emotional neglect and other negative experiences alter the connection between the brain and the gut.

Research Findings

The study showed that when the brain is affected by stress at an early age, it also impacts the gastrointestinal system, as these two systems interact continuously 24 hours a day. Experiments conducted on mice revealed that stress-induced changes differ by biological sex: in females, it often manifests as diarrhea, while in males, it presents as constipation.

Scientists have determined that different symptoms are driven by different biological mechanisms:

  • The sympathetic nervous system is responsible for intestinal motility.

  • Serotonin affects both pain perception and motility.

  • Sex hormones play a significant role in pain perception.

These findings suggest that an individualized approach, rather than a single standard, is necessary when treating gastrointestinal problems.

Large-scale studies, including observations of more than 40,000 infants in Denmark, have shown that untreated maternal depression during pregnancy or postpartum increases the risk of digestive disorders in children, such as colic and Irritable Bowel Syndrome (IBS). The study’s authors emphasize that caring for maternal mental health is a preventive measure for a child’s physical development.

In conclusion, scientists state that it is essential to consider a patient’s childhood history when treating chronic gastrointestinal issues, as early-life stress leaves a long-lasting mark on the brain-gut connection.

eurekalert

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