The U.S. Food and Drug Administration (FDA) is taking decisive measures to prevent a new wave of opioid danger: the focus is on hazardous products containing the kratom compound 7-hydroxymitragynine (7-OH). Due to its concentration, this substance is much stronger than the natural kratom leaf, and consequently, seriously increases the risk of dependence and overdose.
The FDA’s classification of 7-OH as a controlled substance is critical, especially to protect young people and prevent the opioid crisis from escalating.
What Is 7-OH?
7-hydroxymitragynine (7-OH) is a potent alkaloid naturally found in the kratom plant (Mitragyna speciosa). Although kratom leaves are traditionally used to treat pain, anxiety, and opioid withdrawal, 7-OH is a much stronger opioid agonist. 7-OH exists in small amounts in the plant or is synthesized through the conversion of mitragynine.
7-OH is much more dangerous in terms of overdose because even a small amount of it can be fatal compared to the same dose of morphine. It has a high risk of developing tolerance and dependence. Furthermore, it causes the euphoric and sedative effects characteristic of opioids.
7-OH products have rapidly spread on the market, including in vape shops, gas stations, and online spaces. These substances are available in attractive forms such as gummy candies, tablets, drinks, and even ice cream cones. Consumers are often misled and convinced of the harmlessness of these products.
Unlike traditional kratom, which contains only a small amount of 7-OH, these lab-derived concentrates can contain up to 98% pure 7-OH. This is a substance that binds to the brain’s opioid receptors much more strongly than morphine.
Following a thorough scientific review, the FDA warned seven companies for illegally marketing their products as dietary supplements or food. Along with this, the FDA recommends that 7-OH products be restricted under the Controlled Substances Act. This regulatory step will be followed by a public discussion phase, and the final decision will be made by the DEA (Drug Enforcement Administration).
The U.S. Secretary of Health and Human Services, Robert F. Kennedy Jr., emphasizes the danger: “Today’s action against 7-OH is a critical step in the fight against opioid addiction.” Dr. Marty Makary also stated: “After the previous wave of the opioid epidemic, we no longer have the right to be unprepared once again. 7-OH is an opioid stronger than morphine. Regulation and public awareness are essential to avoid another wave of the opioid crisis.”
Strong regulation, public awareness, and constant monitoring are vitally important to protect all consumers from this hidden opioid threat.
